Alpha-1B adrenergic receptor
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Database | Links |
---|---|
UniProt | P35368 |
PDB | Not available |
BioGrid | 106657 |
BindingDB | P35368 |
DrugBank | DB00346, DB00217, DB00298, DB04840, DB01576, DB00590, DB00226, DB01170, DB01018, DB00598, DB01255, DB01577, DB01403, DB00723, DB00211, DB00745, DB01149, DB00368, DB00334, DB01579, DB00388, DB00457, DB00420, DB01608, DB00777, DB01224, DB00734, DB06144, DB00706, DB01162, DB00656 |
Guide to PHARMACOLOGY | 23 |
PharmGKB | PA33 |
KEGG | hsa:147 |
BioCyc | Not available |
Entrez Gene (GeneID) | 147 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9746 | 0.0014 |
Accuracy | 0.9435 | 0.0024 |
Sensitivity | 0.9328 | 0.0032 |
Specificity | 0.9553 | 0.0032 |
BEDROC | 0.994 | 0.0032 |
MCC Threshold | 0.576 | N/A |
MCC | 0.8967 | N/A |
F-score Threshold | 0.52 | N/A |
F-score | 0.9492 | N/A |