TargetNet
P35367
Histamine H1 receptor
Function
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Database Links
| Database | Links |
|---|---|
| UniProt | P35367 |
| PDB | 3RZE |
| BioGrid | 109505 |
| BindingDB | P35367 |
| DrugBank | DB01615, DB00637, DB00719, DB00972, DB00767, DB04890, DB01237, DB00835, DB00354, DB00748, DB00341, DB04837, DB01114, DB01239, DB00568, DB00283, DB00363, DB01176, DB00434, DB01151, DB00967, DB00405, DB00985, DB01075, DB01146, DB01142, DB00366, DB01084, DB00751, DB00950, DB04841, DB00667, DB00557, DB00920, DB01106, DB00455, DB00934, DB00737, DB01071, DB00902, DB01403, DB06148, DB00370, DB00716, DB00334, DB00768, DB01173, DB00885, DB01619, DB01620, DB00433, DB00420, DB01069, DB00777, DB01224, DB00734, DB00342, DB00372, DB00656, DB01246, DB00792, DB00427, DB00246 |
| Guide to PHARMACOLOGY | 262 |
| PharmGKB | PA29456 |
| KEGG | hsa:3269 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3269 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9609 | 0.0021 |
| Accuracy | 0.9013 | 0.0052 |
| Sensitivity | 0.9041 | 0.0064 |
| Specificity | 0.8984 | 0.0069 |
| BEDROC | 0.9918 | 0.0037 |
| MCC Threshold | 0.538 | N/A |
| MCC | 0.8126 | N/A |
| F-score Threshold | 0.434 | N/A |
| F-score | 0.9061 | N/A |