TargetNet
P35354
Prostaglandin G/H synthase 2
Function
Critical component of colonic mucosal wound repair (By similarity). Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
Database Links
| Database | Links |
|---|---|
| UniProt | P35354 |
| PDB | 1V0X |
| BioGrid | 111715 |
| BindingDB | P35354 |
| DrugBank | DB00316, DB00945, DB01014, DB00963, DB00821, DB00482, DB01188, DB00586, DB00861, DB01240, DB00749, DB01628, DB00573, DB00712, DB00154, DB01404, DB01050, DB00159, DB00328, DB01009, DB00465, DB00480, DB01283, DB00939, DB00784, DB00814, DB00244, DB00461, DB00788, DB00991, DB00812, DB00533, DB00936, DB01399, DB00605, DB00870, DB00469, DB01041, DB01600, DB00500, DB00580 |
| Guide to PHARMACOLOGY | 1376 |
| PharmGKB | PA293 |
| KEGG | hsa:5743 |
| BioCyc | MetaCyc:HS01115-MONOMER |
| Entrez Gene (GeneID) | 5743 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9299 | 0.0017 |
| Accuracy | 0.8603 | 0.0017 |
| Sensitivity | 0.8639 | 0.0028 |
| Specificity | 0.8573 | 0.0019 |
| BEDROC | 0.9761 | 0.0019 |
| MCC Threshold | 0.42 | N/A |
| MCC | 0.7235 | N/A |
| F-score Threshold | 0.42 | N/A |
| F-score | 0.8545 | N/A |