TargetNet
P35348
Alpha-1A adrenergic receptor
Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Database Links
| Database | Links |
|---|---|
| UniProt | P35348 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P35348 |
| DrugBank | DB00346, DB01118, DB00182, DB00865, DB00217, DB01136, DB00298, DB04840, DB01576, DB00590, DB00751, DB00668, DB00696, DB00875, DB00226, DB01170, DB00598, DB01255, DB00934, DB01365, DB00610, DB01577, DB01403, DB00723, DB00211, DB01149, DB00699, DB00665, DB00368, DB00506, DB00935, DB00850, DB01579, DB00925, DB00388, DB00397, DB00457, DB00420, DB01069, DB01608, DB00777, DB00852, DB00734, DB06144, DB00706, DB01162, DB00679, DB00797, DB00656, DB00831, DB00246 |
| Guide to PHARMACOLOGY | 22 |
| PharmGKB | PA34 |
| KEGG | hsa:148 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 148 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9859 | 0.0015 |
| Accuracy | 0.9541 | 0.0018 |
| Sensitivity | 0.9373 | 0.0045 |
| Specificity | 0.9694 | 0.0033 |
| BEDROC | 0.9998 | 1.0257 × 10-4 |
| MCC Threshold | 0.438 | N/A |
| MCC | 0.9119 | N/A |
| F-score Threshold | 0.438 | N/A |
| F-score | 0.9539 | N/A |