TargetNet
P35346
Somatostatin receptor type 5
Function
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
Database Links
| Database | Links |
|---|---|
| UniProt | P35346 |
| PDB | Not available |
| BioGrid | 112633 |
| BindingDB | P35346 |
| DrugBank | DB00104 |
| Guide to PHARMACOLOGY | 359 |
| PharmGKB | PA36158 |
| KEGG | hsa:6755 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6755 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9846 | 0.0012 |
| Accuracy | 0.9531 | 0.0035 |
| Sensitivity | 0.9553 | 0.005 |
| Specificity | 0.9503 | 0.0048 |
| BEDROC | 0.9934 | 0.0078 |
| MCC Threshold | 0.458 | N/A |
| MCC | 0.9123 | N/A |
| F-score Threshold | 0.458 | N/A |
| F-score | 0.9608 | N/A |