TargetNet
P35236
Tyrosine-protein phosphatase non-receptor type 7
Function
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Database Links
| Database | Links |
|---|---|
| UniProt | P35236 |
| PDB | 1ZC0, 2A3K, 2GP0, 2GPH, 2HVL, 2QDC, 2QDM, 2QDP, 3D42, 3D44, 3O4S, 3O4T, 3O4U |
| BioGrid | 111743 |
| BindingDB | P35236 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA34003 |
| KEGG | hsa:5778 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5778 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8037 | 0.0108 |
| Accuracy | 0.741 | 0.013 |
| Sensitivity | 0.6526 | 0.0133 |
| Specificity | 0.8195 | 0.0197 |
| BEDROC | 0.9453 | 0.0232 |
| MCC Threshold | 0.726 | N/A |
| MCC | 0.5071 | N/A |
| F-score Threshold | 0.464 | N/A |
| F-score | 0.7192 | N/A |