Nitric oxide synthase, inducible
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Database | Links |
---|---|
UniProt | P35228 |
PDB | 1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4NOS |
BioGrid | 110906 |
BindingDB | P35228 |
DrugBank | DB01234, DB00741, DB00125, DB00155 |
Guide to PHARMACOLOGY | 1250 |
PharmGKB | PA164724093 |
KEGG | hsa:4843 |
BioCyc | MetaCyc:HS00205-MONOMER |
Entrez Gene (GeneID) | 4843 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9108 | 0.0039 |
Accuracy | 0.8521 | 0.0032 |
Sensitivity | 0.8653 | 0.0098 |
Specificity | 0.8388 | 0.007 |
BEDROC | 0.965 | 0.0048 |
MCC Threshold | 0.438 | N/A |
MCC | 0.7169 | N/A |
F-score Threshold | 0.438 | N/A |
F-score | 0.8632 | N/A |