TargetNet
P34998
Corticotropin-releasing factor receptor 1
Function
G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Database Links
| Database | Links |
|---|---|
| UniProt | P34998 |
| PDB | 2L27, 3EHS, 3EHT, 3EHU, 4K5Y |
| BioGrid | 107784 |
| BindingDB | P34998 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 212 |
| PharmGKB | PA26874 |
| KEGG | hsa:1394 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1394 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9872 | 8.5589 × 10-4 |
| Accuracy | 0.9569 | 0.0015 |
| Sensitivity | 0.9682 | 0.0023 |
| Specificity | 0.945 | 0.0011 |
| BEDROC | 0.9972 | 0.0019 |
| MCC Threshold | 0.416 | N/A |
| MCC | 0.9174 | N/A |
| F-score Threshold | 0.416 | N/A |
| F-score | 0.9602 | N/A |