TargetNet
P34995
Prostaglandin E2 receptor EP1 subtype
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
Database Links
| Database | Links |
|---|---|
| UniProt | P34995 |
| PDB | Not available |
| BioGrid | 111703 |
| BindingDB | P34995 |
| DrugBank | DB00770, DB00905, DB00297, DB00429 |
| Guide to PHARMACOLOGY | 340 |
| PharmGKB | PA286 |
| KEGG | hsa:5731 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5731 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9695 | 0.004 |
| Accuracy | 0.9214 | 0.0064 |
| Sensitivity | 0.918 | 0.0048 |
| Specificity | 0.9246 | 0.0105 |
| BEDROC | 0.9992 | 1.4143 × 10-4 |
| MCC Threshold | 0.456 | N/A |
| MCC | 0.8466 | N/A |
| F-score Threshold | 0.456 | N/A |
| F-score | 0.9225 | N/A |