Kappa-type opioid receptor
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Database | Links |
---|---|
UniProt | P34975 |
PDB | Not available |
BioGrid | Not available |
BindingDB | P34975 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 318 |
PharmGKB | Not available |
KEGG | rno:29335 |
BioCyc | Not available |
Entrez Gene (GeneID) | 29335 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9266 | 0.0065 |
Accuracy | 0.8603 | 0.0128 |
Sensitivity | 0.8662 | 0.0151 |
Specificity | 0.8536 | 0.0218 |
BEDROC | 0.9977 | 0.0014 |
MCC Threshold | 0.74 | N/A |
MCC | 0.704 | N/A |
F-score Threshold | 0.394 | N/A |
F-score | 0.8589 | N/A |