TargetNet
P34969
5-hydroxytryptamine receptor 7
Function
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Database Links
| Database | Links |
|---|---|
| UniProt | P34969 |
| PDB | Not available |
| BioGrid | 109595 |
| BindingDB | P34969 |
| DrugBank | DB00216, DB00247, DB00246 |
| Guide to PHARMACOLOGY | 12 |
| PharmGKB | PA29561 |
| KEGG | hsa:3363 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3363 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9662 | 0.0016 |
| Accuracy | 0.9171 | 0.0033 |
| Sensitivity | 0.9039 | 0.0065 |
| Specificity | 0.9284 | 0.0046 |
| BEDROC | 0.986 | 0.0068 |
| MCC Threshold | 0.48 | N/A |
| MCC | 0.8304 | N/A |
| F-score Threshold | 0.448 | N/A |
| F-score | 0.9092 | N/A |