TargetNet
P34913
Bifunctional epoxide hydrolase 2
Function
Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.
Database Links
| Database | Links |
|---|---|
| UniProt | P34913 |
| PDB | 1S8O, 1VJ5, 1ZD2, 1ZD3, 1ZD4, 1ZD5, 3ANS, 3ANT, 3I1Y, 3I28, 3KOO, 3OTQ, 3PDC, 4HAI, 4J03, 4JNC |
| BioGrid | 108367 |
| BindingDB | P34913 |
| DrugBank | DB00675 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA27830 |
| KEGG | hsa:2053 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2053 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9811 | 8.0479 × 10-4 |
| Accuracy | 0.9442 | 0.0023 |
| Sensitivity | 0.9368 | 0.0039 |
| Specificity | 0.9511 | 0.0026 |
| BEDROC | 0.9974 | 8.4744 × 10-4 |
| MCC Threshold | 0.466 | N/A |
| MCC | 0.8961 | N/A |
| F-score Threshold | 0.466 | N/A |
| F-score | 0.9463 | N/A |