TargetNet
P33533
Delta-type opioid receptor
Function
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Database Links
| Database | Links |
|---|---|
| UniProt | P33533 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P33533 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 317 |
| PharmGKB | Not available |
| KEGG | rno:24613 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24613 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9815 | 8.8437 × 10-4 |
| Accuracy | 0.9465 | 0.002 |
| Sensitivity | 0.9478 | 0.0034 |
| Specificity | 0.9453 | 0.003 |
| BEDROC | 0.9935 | 0.0029 |
| MCC Threshold | 0.468 | N/A |
| MCC | 0.8957 | N/A |
| F-score Threshold | 0.468 | N/A |
| F-score | 0.9465 | N/A |