Cytochrome P450 2C19
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Database | Links |
---|---|
UniProt | P33261 |
PDB | 4GQS |
BioGrid | 107935 |
BindingDB | P33261 |
DrugBank | DB00546, DB01424, DB00321, DB01060, DB01274, DB00188, DB00395, DB00356, DB01166, DB00215, DB01211, DB00349, DB01151, DB00967, DB00586, DB00343, DB00625, DB00736, DB00927, DB00949, DB01216, DB01544, DB00176, DB00983, DB01320, DB01018, DB00458, DB00328, DB01026, DB00448, DB01259, DB00455, DB01065, DB00532, DB00333, DB00849, DB01171, DB00745, DB00220, DB00622, DB00665, DB00506, DB00338, DB00776, DB00213, DB00738, DB01174, DB00252, DB00794, DB00396, DB01131, DB00420, DB00908, DB01129, DB00863, DB00503, DB01037, DB01104, DB00231, DB00444, DB00342, DB01041, DB00679, DB00208, DB01124, DB00273, DB00752, DB00197, DB01361, DB00582 |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA124 |
KEGG | hsa:1557 |
BioCyc | MetaCyc:HS09293-MONOMER |
Entrez Gene (GeneID) | 1557 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.7945 | 0.0112 |
Accuracy | 0.7275 | 0.0122 |
Sensitivity | 0.6811 | 0.0185 |
Specificity | 0.7692 | 0.0139 |
BEDROC | 0.9148 | 0.0189 |
MCC Threshold | 0.46 | N/A |
MCC | 0.4926 | N/A |
F-score Threshold | 0.458 | N/A |
F-score | 0.7408 | N/A |