TargetNet
P33032
Melanocortin receptor 5
Function
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
Database Links
| Database | Links |
|---|---|
| UniProt | P33032 |
| PDB | Not available |
| BioGrid | 110331 |
| BindingDB | P33032 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 286 |
| PharmGKB | PA30677 |
| KEGG | hsa:4161 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4161 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9299 | 0.0036 |
| Accuracy | 0.8557 | 0.0101 |
| Sensitivity | 0.8746 | 0.0127 |
| Specificity | 0.834 | 0.0159 |
| BEDROC | 0.9919 | 0.0073 |
| MCC Threshold | 0.692 | N/A |
| MCC | 0.7253 | N/A |
| F-score Threshold | 0.418 | N/A |
| F-score | 0.8583 | N/A |