TargetNet
P32305
5-hydroxytryptamine receptor 7
Function
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This receptor is implicated in the regulation of mammalian circadian rhythms.
Database Links
| Database | Links |
|---|---|
| UniProt | P32305 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P32305 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 12 |
| PharmGKB | Not available |
| KEGG | rno:65032 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 65032 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9725 | 0.0023 |
| Accuracy | 0.9204 | 0.0029 |
| Sensitivity | 0.9267 | 0.0043 |
| Specificity | 0.9126 | 0.0054 |
| BEDROC | 0.9924 | 0.0067 |
| MCC Threshold | 0.566 | N/A |
| MCC | 0.8425 | N/A |
| F-score Threshold | 0.424 | N/A |
| F-score | 0.9311 | N/A |