Delta-type opioid receptor
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Database | Links |
---|---|
UniProt | P32300 |
PDB | 4EJ4 |
BioGrid | Not available |
BindingDB | P32300 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 317 |
PharmGKB | Not available |
KEGG | mmu:18386 |
BioCyc | Not available |
Entrez Gene (GeneID) | 18386 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9575 | 0.0019 |
Accuracy | 0.9112 | 0.0035 |
Sensitivity | 0.9332 | 0.0058 |
Specificity | 0.8845 | 0.0062 |
BEDROC | 0.9758 | 0.006 |
MCC Threshold | 0.4 | N/A |
MCC | 0.8376 | N/A |
F-score Threshold | 0.4 | N/A |
F-score | 0.9287 | N/A |