TargetNet
P32246
C-C chemokine receptor type 1
Function
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Database Links
| Database | Links |
|---|---|
| UniProt | P32246 |
| PDB | 1Y5D |
| BioGrid | 107635 |
| BindingDB | P32246 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 58 |
| PharmGKB | PA26166 |
| KEGG | hsa:1230 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1230 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9809 | 0.0013 |
| Accuracy | 0.948 | 0.0032 |
| Sensitivity | 0.9576 | 0.0049 |
| Specificity | 0.9397 | 0.0045 |
| BEDROC | 0.9901 | 0.0048 |
| MCC Threshold | 0.514 | N/A |
| MCC | 0.9024 | N/A |
| F-score Threshold | 0.514 | N/A |
| F-score | 0.9483 | N/A |