TargetNet
P32245
Melanocortin receptor 4
Function
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Database Links
| Database | Links |
|---|---|
| UniProt | P32245 |
| PDB | 2IQP, 2IQR, 2IQS, 2IQU, 2IQV, 2IQW |
| BioGrid | 110330 |
| BindingDB | P32245 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 285 |
| PharmGKB | PA30676 |
| KEGG | hsa:4160 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4160 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9729 | 8.8133 × 10-4 |
| Accuracy | 0.942 | 0.0024 |
| Sensitivity | 0.9462 | 0.0033 |
| Specificity | 0.9374 | 0.0038 |
| BEDROC | 0.9832 | 0.0052 |
| MCC Threshold | 0.468 | N/A |
| MCC | 0.8793 | N/A |
| F-score Threshold | 0.468 | N/A |
| F-score | 0.9425 | N/A |