TargetNet
P32240
Prostaglandin E2 receptor EP4 subtype
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Database Links
| Database | Links |
|---|---|
| UniProt | P32240 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P32240 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 343 |
| PharmGKB | Not available |
| KEGG | mmu:19219 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 19219 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9658 | 0.0021 |
| Accuracy | 0.9273 | 0.0086 |
| Sensitivity | 0.9134 | 0.0064 |
| Specificity | 0.9409 | 0.014 |
| BEDROC | 0.9998 | 3.3243 × 10-5 |
| MCC Threshold | 0.51 | N/A |
| MCC | 0.8744 | N/A |
| F-score Threshold | 0.452 | N/A |
| F-score | 0.9353 | N/A |