TargetNet
P32239
Gastrin/cholecystokinin type B receptor
Function
Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P32239 |
| PDB | 1L4T |
| BioGrid | 107329 |
| BindingDB | P32239 |
| DrugBank | DB00183 |
| Guide to PHARMACOLOGY | 77 |
| PharmGKB | PA26143 |
| KEGG | hsa:887 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 887 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9751 | 0.0015 |
| Accuracy | 0.9255 | 0.0029 |
| Sensitivity | 0.9385 | 0.0057 |
| Specificity | 0.9131 | 0.0036 |
| BEDROC | 0.9937 | 0.0028 |
| MCC Threshold | 0.568 | N/A |
| MCC | 0.8635 | N/A |
| F-score Threshold | 0.568 | N/A |
| F-score | 0.9303 | N/A |