TargetNet
P32238
Cholecystokinin receptor type A
Function
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P32238 |
| PDB | 1D6G, 1HZN, 1PB2 |
| BioGrid | 107328 |
| BindingDB | P32238 |
| DrugBank | DB00403 |
| Guide to PHARMACOLOGY | 76 |
| PharmGKB | PA26142 |
| KEGG | hsa:886 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 886 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9806 | 0.0011 |
| Accuracy | 0.9452 | 0.0032 |
| Sensitivity | 0.9584 | 0.0044 |
| Specificity | 0.9292 | 0.004 |
| BEDROC | 0.9953 | 0.0047 |
| MCC Threshold | 0.424 | N/A |
| MCC | 0.8918 | N/A |
| F-score Threshold | 0.424 | N/A |
| F-score | 0.9519 | N/A |