TargetNet
P31941
DNA dC->dU-editing enzyme APOBEC-3A
Function
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Database Links
| Database | Links |
|---|---|
| UniProt | P31941 |
| PDB | 2M65 |
| BioGrid | 128318 |
| BindingDB | P31941 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA24891 |
| KEGG | hsa:100913187, hsa:200315 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 100913187, 200315 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9253 | 0.0036 |
| Accuracy | 0.8337 | 0.0061 |
| Sensitivity | 0.8371 | 0.0091 |
| Specificity | 0.8308 | 0.0079 |
| BEDROC | 0.9688 | 0.0045 |
| MCC Threshold | 0.344 | N/A |
| MCC | 0.6753 | N/A |
| F-score Threshold | 0.344 | N/A |
| F-score | 0.8317 | N/A |