TargetNet
P31645
Sodium-dependent serotonin transporter
Function
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Database Links
| Database | Links |
|---|---|
| UniProt | P31645 |
| PDB | Not available |
| BioGrid | 112423 |
| BindingDB | P31645 |
| DrugBank | DB04836, DB00321, DB00543, DB00215, DB01242, DB00907, DB01151, DB01191, DB00514, DB01142, DB00476, DB01175, DB00472, DB00176, DB00458, DB00422, DB04896, DB00805, DB01149, DB00540, DB00715, DB00191, DB00344, DB01104, DB01105, DB01079, DB00193, DB00656, DB00726, DB00285, DB04832 |
| Guide to PHARMACOLOGY | 928 |
| PharmGKB | PA312 |
| KEGG | hsa:6532 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6532 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9555 | 9.3943 × 10-4 |
| Accuracy | 0.9129 | 0.0021 |
| Sensitivity | 0.9269 | 0.0025 |
| Specificity | 0.8976 | 0.0028 |
| BEDROC | 0.9568 | 0.0038 |
| MCC Threshold | 0.428 | N/A |
| MCC | 0.8315 | N/A |
| F-score Threshold | 0.428 | N/A |
| F-score | 0.9216 | N/A |