TargetNet
P31424
Metabotropic glutamate receptor 5
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Database Links
| Database | Links |
|---|---|
| UniProt | P31424 |
| PDB | 1DDV |
| BioGrid | 246583 |
| BindingDB | P31424 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 293 |
| PharmGKB | Not available |
| KEGG | rno:24418 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24418 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9648 | 0.003 |
| Accuracy | 0.9085 | 0.0038 |
| Sensitivity | 0.904 | 0.0059 |
| Specificity | 0.9124 | 0.0059 |
| BEDROC | 0.9951 | 0.0012 |
| MCC Threshold | 0.486 | N/A |
| MCC | 0.827 | N/A |
| F-score Threshold | 0.486 | N/A |
| F-score | 0.9078 | N/A |