TargetNet
P31421
Metabotropic glutamate receptor 2
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Database Links
| Database | Links |
|---|---|
| UniProt | P31421 |
| PDB | Not available |
| BioGrid | 246580 |
| BindingDB | P31421 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 290 |
| PharmGKB | Not available |
| KEGG | rno:24415 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24415 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9701 | 0.0017 |
| Accuracy | 0.9304 | 0.003 |
| Sensitivity | 0.9361 | 0.006 |
| Specificity | 0.9241 | 0.0046 |
| BEDROC | 0.9994 | 4.9506 × 10-4 |
| MCC Threshold | 0.594 | N/A |
| MCC | 0.8808 | N/A |
| F-score Threshold | 0.594 | N/A |
| F-score | 0.9414 | N/A |