TargetNet
P31391
Somatostatin receptor type 4
Function
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.
Database Links
| Database | Links |
|---|---|
| UniProt | P31391 |
| PDB | Not available |
| BioGrid | 112632 |
| BindingDB | P31391 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 358 |
| PharmGKB | PA36157 |
| KEGG | hsa:6754 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6754 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9843 | 0.0013 |
| Accuracy | 0.9497 | 0.0031 |
| Sensitivity | 0.9511 | 0.0058 |
| Specificity | 0.9485 | 0.0034 |
| BEDROC | 0.9822 | 0.011 |
| MCC Threshold | 0.398 | N/A |
| MCC | 0.9069 | N/A |
| F-score Threshold | 0.398 | N/A |
| F-score | 0.9511 | N/A |