TargetNet
P31388
5-hydroxytryptamine receptor 6
Function
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.
Database Links
| Database | Links |
|---|---|
| UniProt | P31388 |
| PDB | Not available |
| BioGrid | 249039 |
| BindingDB | P31388 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 11 |
| PharmGKB | Not available |
| KEGG | rno:64354 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 64354 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9583 | 0.0059 |
| Accuracy | 0.8875 | 0.0113 |
| Sensitivity | 0.8793 | 0.0195 |
| Specificity | 0.8947 | 0.0157 |
| BEDROC | 0.9975 | 0.0012 |
| MCC Threshold | 0.528 | N/A |
| MCC | 0.8073 | N/A |
| F-score Threshold | 0.528 | N/A |
| F-score | 0.8919 | N/A |