TargetNet
P31213
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Function
Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Database Links
| Database | Links |
|---|---|
| UniProt | P31213 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P31213 |
| DrugBank | DB00548, DB01126 |
| Guide to PHARMACOLOGY | 2633 |
| PharmGKB | PA36113 |
| KEGG | hsa:6716 |
| BioCyc | MetaCyc:HS00619-MONOMER |
| Entrez Gene (GeneID) | 6716 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9748 | 0.0023 |
| Accuracy | 0.9316 | 0.0042 |
| Sensitivity | 0.9597 | 0.0062 |
| Specificity | 0.9 | 0.0054 |
| BEDROC | 0.9935 | 0.0047 |
| MCC Threshold | 0.63 | N/A |
| MCC | 0.8755 | N/A |
| F-score Threshold | 0.63 | N/A |
| F-score | 0.9406 | N/A |