TargetNet
P30969
Gonadotropin-releasing hormone receptor
Function
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P30969 |
| PDB | Not available |
| BioGrid | 249567 |
| BindingDB | P30969 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 256 |
| PharmGKB | Not available |
| KEGG | rno:81668 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 81668 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9896 | 0.0014 |
| Accuracy | 0.9593 | 0.0021 |
| Sensitivity | 0.9716 | 0.0036 |
| Specificity | 0.9452 | 0.0021 |
| BEDROC | 0.9998 | 6.1721 × 10-5 |
| MCC Threshold | 0.626 | N/A |
| MCC | 0.9135 | N/A |
| F-score Threshold | 0.558 | N/A |
| F-score | 0.9599 | N/A |