Gonadotropin-releasing hormone receptor
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
Database | Links |
---|---|
UniProt | P30968 |
PDB | Not available |
BioGrid | 109060 |
BindingDB | P30968 |
DrugBank | DB00106, DB00050, DB01406, DB00644, DB00007, DB00666 |
Guide to PHARMACOLOGY | 256 |
PharmGKB | PA28800 |
KEGG | hsa:2798 |
BioCyc | Not available |
Entrez Gene (GeneID) | 2798 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.992 | 7.9057 × 10-4 |
Accuracy | 0.9739 | 0.001 |
Sensitivity | 0.9836 | 0.0023 |
Specificity | 0.9647 | 0.0017 |
BEDROC | 0.9938 | 0.0044 |
MCC Threshold | 0.45 | N/A |
MCC | 0.9497 | N/A |
F-score Threshold | 0.45 | N/A |
F-score | 0.9744 | N/A |