TargetNet
P30939
5-hydroxytryptamine receptor 1F
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Database Links
| Database | Links |
|---|---|
| UniProt | P30939 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P30939 |
| DrugBank | DB00216, DB00952, DB00953, DB00669, DB00315 |
| Guide to PHARMACOLOGY | 5 |
| PharmGKB | PA29553 |
| KEGG | hsa:3355 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3355 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9281 | 0.0071 |
| Accuracy | 0.8636 | 0.0134 |
| Sensitivity | 0.8477 | 0.0153 |
| Specificity | 0.8826 | 0.0207 |
| BEDROC | 0.9996 | 1.4045 × 10-4 |
| MCC Threshold | 0.548 | N/A |
| MCC | 0.7194 | N/A |
| F-score Threshold | 0.388 | N/A |
| F-score | 0.8676 | N/A |