TargetNet
P30872
Somatostatin receptor type 1
Function
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
Database Links
| Database | Links |
|---|---|
| UniProt | P30872 |
| PDB | Not available |
| BioGrid | 112629 |
| BindingDB | P30872 |
| DrugBank | DB00104 |
| Guide to PHARMACOLOGY | 355 |
| PharmGKB | PA36154 |
| KEGG | hsa:6751 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6751 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.98 | 0.0017 |
| Accuracy | 0.9291 | 0.0035 |
| Sensitivity | 0.9334 | 0.0064 |
| Specificity | 0.9241 | 0.0074 |
| BEDROC | 0.9993 | 5.5412 × 10-4 |
| MCC Threshold | 0.276 | N/A |
| MCC | 0.8636 | N/A |
| F-score Threshold | 0.276 | N/A |
| F-score | 0.9379 | N/A |