TargetNet
P30557
Prostaglandin E2 receptor EP3 subtype
Function
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. The various forms can interact with different second messenger systems.
Database Links
| Database | Links |
|---|---|
| UniProt | P30557 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P30557 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 342 |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9632 | 0.0059 |
| Accuracy | 0.9168 | 0.0047 |
| Sensitivity | 0.9257 | 0.0033 |
| Specificity | 0.9081 | 0.009 |
| BEDROC | 0.9981 | 0.001 |
| MCC Threshold | 0.592 | N/A |
| MCC | 0.8424 | N/A |
| F-score Threshold | 0.418 | N/A |
| F-score | 0.9202 | N/A |