TargetNet
P30553
Gastrin/cholecystokinin type B receptor
Function
Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P30553 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P30553 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 77 |
| PharmGKB | Not available |
| KEGG | rno:25706 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 25706 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9633 | 0.0028 |
| Accuracy | 0.9137 | 0.0078 |
| Sensitivity | 0.8939 | 0.0066 |
| Specificity | 0.9326 | 0.0132 |
| BEDROC | 0.9993 | 4.6094 × 10-4 |
| MCC Threshold | 0.496 | N/A |
| MCC | 0.8491 | N/A |
| F-score Threshold | 0.496 | N/A |
| F-score | 0.9214 | N/A |