TargetNet
P30551
Cholecystokinin receptor type A
Function
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P30551 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P30551 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 76 |
| PharmGKB | Not available |
| KEGG | rno:24889 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24889 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9505 | 0.002 |
| Accuracy | 0.9088 | 0.0038 |
| Sensitivity | 0.9287 | 0.006 |
| Specificity | 0.8871 | 0.0049 |
| BEDROC | 0.9574 | 0.0096 |
| MCC Threshold | 0.38 | N/A |
| MCC | 0.8239 | N/A |
| F-score Threshold | 0.38 | N/A |
| F-score | 0.9181 | N/A |