TargetNet
P30305
M-phase inducer phosphatase 2
Function
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
Database Links
| Database | Links |
|---|---|
| UniProt | P30305 |
| PDB | 1CWR, 1CWS, 1CWT, 1QB0, 1YM9, 1YMD, 1YMK, 1YML, 1YS0, 2A2K, 2IFD, 2IFV, 2UZQ, 3FQT, 3FQU |
| BioGrid | 107429 |
| BindingDB | P30305 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA26260 |
| KEGG | hsa:994 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 994 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.906 | 0.0068 |
| Accuracy | 0.8024 | 0.0085 |
| Sensitivity | 0.8632 | 0.0114 |
| Specificity | 0.74 | 0.0123 |
| BEDROC | 0.9804 | 0.0069 |
| MCC Threshold | 0.234 | N/A |
| MCC | 0.6495 | N/A |
| F-score Threshold | 0.234 | N/A |
| F-score | 0.836 | N/A |