TargetNet
P29597
Non-receptor tyrosine-protein kinase TYK2
Function
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Database Links
| Database | Links |
|---|---|
| UniProt | P29597 |
| PDB | 3LXN, 3LXP, 3NYX, 3NZ0, 3ZON, 4GFO, 4GIH, 4GII, 4GJ2, 4GJ3, 4GVJ |
| BioGrid | 113148 |
| BindingDB | P29597 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2269 |
| PharmGKB | PA37094 |
| KEGG | hsa:7297 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 7297 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8297 | 0.0148 |
| Accuracy | 0.7494 | 0.0191 |
| Sensitivity | 0.7468 | 0.031 |
| Specificity | 0.7522 | 0.0149 |
| BEDROC | 0.8857 | 0.0293 |
| MCC Threshold | 0.576 | N/A |
| MCC | 0.5951 | N/A |
| F-score Threshold | 0.466 | N/A |
| F-score | 0.7985 | N/A |