TargetNet
P29477
Nitric oxide synthase, inducible
Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Database Links
| Database | Links |
|---|---|
| UniProt | P29477 |
| PDB | 1DD7, 1DF1, 1DWV, 1DWW, 1DWX, 1JWJ, 1JWK, 1M8D, 1M8E, 1M8H, 1M8I, 1M9T, 1N2N, 1NOC, 1NOD, 1NOS, 1QOM, 1QW4, 1QW5, 1R35, 1VAF, 2BHJ, 2NOD, 2NOS, 2ORO, 2ORP, 2ORQ, 2ORR, 2ORS, 2ORT, 2Y37, 3DWJ, 3E65, 3E67, 3E68, 3E6L, 3E6N, 3E6O, 3E6T, 3E7I, 3E7M, 3E7T, 3EAI, 3EBD, 3EBF, 3GOF, 3NOD, 3NQS, 3NW2 |
| BioGrid | 201806 |
| BindingDB | P29477 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | mmu:18126 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 18126 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8212 | 0.0144 |
| Accuracy | 0.7568 | 0.0161 |
| Sensitivity | 0.744 | 0.0207 |
| Specificity | 0.7686 | 0.0178 |
| BEDROC | 0.9776 | 0.0127 |
| MCC Threshold | 0.524 | N/A |
| MCC | 0.5363 | N/A |
| F-score Threshold | 0.524 | N/A |
| F-score | 0.7536 | N/A |