P29476

Nitric oxide synthase, brain

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non- adrenergic and non-cholinergic nerves in the colorectum.

Database Links

Database	Links
UniProt	P29476
PDB	1B8Q, 1CMI, 1F20, 1K2R, 1K2S, 1K2T, 1K2U, 1LZX, 1LZZ, 1M00, 1MMV, 1MMW, 1OM4, 1OM5, 1P6H, 1P6I, 1P6J, 1P6K, 1QAU, 1QAV, 1QW6, 1QWC, 1RS6, 1RS7, 1TLL, 1VAG, 1ZVI, 1ZVL, 1ZZQ, 1ZZR, 1ZZU, 2G6H, 2G6I, 2G6J, 2G6K, 2G6L, 2G6M, 2G6N, 2HX3, 2HX4, 3B3M, 3B3N, 3B3O, 3B3P, 3DQR, 3FC5, 3HSN, 3HSO, 3HSP, 3JT3, 3JT4, 3JT5, 3JT6, 3JT7, 3JT8, 3JT9, 3JTA, 3JWS, 3JWT, 3JWU, 3JWV, 3JX0, 3JX1, 3JX2, 3JX3, 3JX4, 3JX5, 3JX6, 3N2R, 3N5V, 3N5W, 3N5X, 3N5Y, 3N5Z, 3N60, 3N61, 3N62, 3N63, 3N64, 3N65, 3N66, 3N67, 3N68, 3N69, 3N6A, 3N6B, 3N6C, 3N6D, 3N6E, 3N6F, 3N6G, 3NLJ, 3NLK, 3NLM, 3NLN, 3NLO, 3NLP, 3NLQ, 3NLR, 3NLV, 3NLW, 3NLX, 3NLY, 3NLZ, 3NM0, 3NNY, 3NNZ, 3PNE, 3PNF, 3PNG, 3Q99, 3Q9A, 3RQJ, 3RQK, 3RQL, 3RQM, 3RQN, 3SVP, 3SVQ, 3TYL, 3TYM, 3TYN, 3TYO, 3UFO, 3UFP, 3UFQ, 3UFR, 3UFS, 3UFT, 3UFU, 3UFV, 3UFW, 4EUX, 4FVW, 4FVX, 4FVY, 4FVZ, 4FW0, 4GQE, 4HOP, 4IMS, 4IMT, 4IMU, 4IMW, 4JSE, 4JSF, 4JSG, 4JSH, 4JSI, 4JSJ, 4K5D, 4K5E, 4K5F, 4K5G, 4LUX
BioGrid	246738
BindingDB	P29476
DrugBank	Not available
Guide to PHARMACOLOGY	1251
PharmGKB	Not available
KEGG	rno:24598
BioCyc	Not available
Entrez Gene (GeneID)	24598

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9004	0.007
Accuracy	0.8304	0.0085
Sensitivity	0.843	0.0168
Specificity	0.8162	0.0155
BEDROC	0.9786	0.0113
MCC Threshold	0.678	N/A
MCC	0.6878	N/A
F-score Threshold	0.456	N/A
F-score	0.8503	N/A

Downloads

R Model Object

Random Forest model object (.RData)

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Positive Set

SMILES string + affinity value (.tsv)

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TargetNet