TargetNet
P29475
Nitric oxide synthase, brain
Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Database Links
| Database | Links |
|---|---|
| UniProt | P29475 |
| PDB | Not available |
| BioGrid | 110905 |
| BindingDB | P29475 |
| DrugBank | DB00155 |
| Guide to PHARMACOLOGY | 1251 |
| PharmGKB | PA252 |
| KEGG | hsa:4842 |
| BioCyc | MetaCyc:HS01647-MONOMER |
| Entrez Gene (GeneID) | 4842 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9141 | 0.0039 |
| Accuracy | 0.8416 | 0.0058 |
| Sensitivity | 0.8282 | 0.0072 |
| Specificity | 0.8531 | 0.0111 |
| BEDROC | 0.9816 | 0.0066 |
| MCC Threshold | 0.42 | N/A |
| MCC | 0.6906 | N/A |
| F-score Threshold | 0.42 | N/A |
| F-score | 0.8381 | N/A |