TargetNet
P29474
Nitric oxide synthase, endothelial
Function
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Database Links
| Database | Links |
|---|---|
| UniProt | P29474 |
| PDB | 1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS |
| BioGrid | 110909 |
| BindingDB | P29474 |
| DrugBank | DB00125, DB00155, DB01098, DB00360 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA254 |
| KEGG | hsa:4846 |
| BioCyc | MetaCyc:HS09149-MONOMER |
| Entrez Gene (GeneID) | 4846 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8014 | 0.0082 |
| Accuracy | 0.7172 | 0.011 |
| Sensitivity | 0.7229 | 0.0188 |
| Specificity | 0.7121 | 0.0144 |
| BEDROC | 0.9103 | 0.0241 |
| MCC Threshold | 0.318 | N/A |
| MCC | 0.4706 | N/A |
| F-score Threshold | 0.318 | N/A |
| F-score | 0.7452 | N/A |