P29466

Caspase-1

Function

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Database Links

Database	Links
UniProt	P29466
PDB	1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7
BioGrid	107284
BindingDB	P29466
DrugBank	DB01017, DB00859
Guide to PHARMACOLOGY	1617
PharmGKB	PA26083
KEGG	hsa:834
BioCyc	Not available
Entrez Gene (GeneID)	834

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9441	0.0034
Accuracy	0.8835	0.0047
Sensitivity	0.8816	0.0059
Specificity	0.8856	0.0057
BEDROC	0.9903	0.0106
MCC Threshold	0.348	N/A
MCC	0.7868	N/A
F-score Threshold	0.348	N/A
F-score	0.9025	N/A

Downloads

R Model Object

Random Forest model object (.RData)

Download RData

Positive Set

SMILES string + affinity value (.tsv)

Download TSV

TargetNet