TargetNet
P29371
Neuromedin-K receptor
Function
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
Database Links
| Database | Links |
|---|---|
| UniProt | P29371 |
| PDB | Not available |
| BioGrid | 112733 |
| BindingDB | P29371 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 362 |
| PharmGKB | PA36304 |
| KEGG | hsa:6870 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6870 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9833 | 0.0011 |
| Accuracy | 0.944 | 0.0042 |
| Sensitivity | 0.9503 | 0.0047 |
| Specificity | 0.9372 | 0.0062 |
| BEDROC | 0.9974 | 0.0021 |
| MCC Threshold | 0.628 | N/A |
| MCC | 0.9017 | N/A |
| F-score Threshold | 0.562 | N/A |
| F-score | 0.951 | N/A |