TargetNet
P29274
Adenosine receptor A2a
Function
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Database Links
| Database | Links |
|---|---|
| UniProt | P29274 |
| PDB | 1MMH, 1UPE, 2YDO, 2YDV, 3EML, 3PWH, 3QAK, 3REY, 3RFM, 3UZA, 3UZC, 3VG9, 3VGA, 4EIY |
| BioGrid | 106647 |
| BindingDB | P29274 |
| DrugBank | DB00201, DB04932, DB00061, DB00277 |
| Guide to PHARMACOLOGY | 19 |
| PharmGKB | PA24584 |
| KEGG | hsa:135 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 135 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9393 | 7.4923 × 10-4 |
| Accuracy | 0.8948 | 0.0026 |
| Sensitivity | 0.8969 | 0.0045 |
| Specificity | 0.8928 | 0.0025 |
| BEDROC | 0.9109 | 0.0035 |
| MCC Threshold | 0.316 | N/A |
| MCC | 0.8137 | N/A |
| F-score Threshold | 0.316 | N/A |
| F-score | 0.9066 | N/A |