Corticosteroid 11-beta-dehydrogenase isozyme 1
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Database | Links |
---|---|
UniProt | P28845 |
PDB | 1XU7, 1XU9, 2BEL, 2ILT, 2IRW, 2RBE, 3BYZ, 3BZU, 3CH6, 3CZR, 3D3E, 3D4N, 3D5Q, 3EY4, 3FCO, 3FRJ, 3H6K, 3HFG, 3OQ1, 3PDJ, 3QQP, 3TFQ, 4BB5, 4BB6, 4HFR, 4HX5 |
BioGrid | 109523 |
BindingDB | P28845 |
DrugBank | DB00157 |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA29476 |
KEGG | hsa:3290 |
BioCyc | Not available |
Entrez Gene (GeneID) | 3290 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9856 | 4.5796 × 10-4 |
Accuracy | 0.9515 | 0.0018 |
Sensitivity | 0.9481 | 0.0029 |
Specificity | 0.9544 | 0.0013 |
BEDROC | 0.9934 | 0.0017 |
MCC Threshold | 0.562 | N/A |
MCC | 0.9097 | N/A |
F-score Threshold | 0.562 | N/A |
F-score | 0.9506 | N/A |