TargetNet
P28702
Retinoic acid receptor RXR-beta
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA).
Database Links
| Database | Links |
|---|---|
| UniProt | P28702 |
| PDB | 1H9U, 1UHL |
| BioGrid | 112169 |
| BindingDB | P28702 |
| DrugBank | DB00459, DB00210, DB00523, DB00307, DB00926, DB00799, DB00755 |
| Guide to PHARMACOLOGY | 611 |
| PharmGKB | PA34891 |
| KEGG | hsa:6257 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6257 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.986 | 0.0017 |
| Accuracy | 0.9575 | 0.0058 |
| Sensitivity | 0.9549 | 0.0106 |
| Specificity | 0.9598 | 0.0025 |
| BEDROC | 0.9885 | 0.0096 |
| MCC Threshold | 0.42 | N/A |
| MCC | 0.9333 | N/A |
| F-score Threshold | 0.42 | N/A |
| F-score | 0.9649 | N/A |