TargetNet
P28566
5-hydroxytryptamine receptor 1E
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Database Links
| Database | Links |
|---|---|
| UniProt | P28566 |
| PDB | Not available |
| BioGrid | 109586 |
| BindingDB | P28566 |
| DrugBank | DB00216 |
| Guide to PHARMACOLOGY | 4 |
| PharmGKB | PA29552 |
| KEGG | hsa:3354 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3354 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7924 | 0.0184 |
| Accuracy | 0.7044 | 0.0172 |
| Sensitivity | 0.6595 | 0.0304 |
| Specificity | 0.7465 | 0.0155 |
| BEDROC | 0.9078 | 0.0147 |
| MCC Threshold | 0.406 | N/A |
| MCC | 0.4901 | N/A |
| F-score Threshold | 0.406 | N/A |
| F-score | 0.7599 | N/A |