5-hydroxytryptamine receptor 1B
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Database | Links |
---|---|
UniProt | P28564 |
PDB | Not available |
BioGrid | Not available |
BindingDB | P28564 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 2 |
PharmGKB | Not available |
KEGG | rno:25075 |
BioCyc | Not available |
Entrez Gene (GeneID) | 25075 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9025 | 0.0081 |
Accuracy | 0.8264 | 0.0088 |
Sensitivity | 0.8265 | 0.0158 |
Specificity | 0.8263 | 0.0103 |
BEDROC | 0.9919 | 0.0035 |
MCC Threshold | 0.614 | N/A |
MCC | 0.6623 | N/A |
F-score Threshold | 0.418 | N/A |
F-score | 0.8455 | N/A |