5-hydroxytryptamine receptor 2C
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1- 2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Database | Links |
---|---|
UniProt | P28335 |
PDB | Not available |
BioGrid | 109590 |
BindingDB | P28335 |
DrugBank | DB01239, DB00363, DB01191, DB00574, DB00247, DB06148, DB00805, DB00370, DB00334, DB00420, DB00777, DB01224, DB06144, DB00372, DB00193, DB00246 |
Guide to PHARMACOLOGY | 8 |
PharmGKB | PA194 |
KEGG | hsa:3358 |
BioCyc | Not available |
Entrez Gene (GeneID) | 3358 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9454 | 0.0013 |
Accuracy | 0.8865 | 0.0018 |
Sensitivity | 0.9009 | 0.0031 |
Specificity | 0.8691 | 0.0037 |
BEDROC | 0.9918 | 0.0023 |
MCC Threshold | 0.47 | N/A |
MCC | 0.7773 | N/A |
F-score Threshold | 0.448 | N/A |
F-score | 0.9012 | N/A |